Metformin inhibits orofacial neuropathy through p-AMPK/p-mTOR-mediated p-p38 MAPK activation in streptozotocin-induced diabetic neuropathic mice
Jihee Yeo, Roh Dea-Hyun · FENS Forum 2024
We aimed to determine facial and hind paw allodynia in diabetic neuropathy model induced by streptozotocin (STZ) treatment and to determine the anti-allodynic effect of metformin treatment. STZ was intraperitoneally injected (150 mg/kg) to induce painful diabetic neuropathy, and 200 mg/kg of metformin was injected intraperitoneally on the 21st day. Both of the mechanical and cold sensitivity in facial and paw withdrawal region were quantified using von-Frey filaments and acetone solution, respectively. To test heat hyperalgesia, mice were placed into a plastic chamber with a glass floor and ra
ePoster · Neuroscience