CD8 T cells play a major role in CNS inflammation and brain atrophy in type I interferon-mediated neuroinflammation of RNaseT2-deficient mice
Matthias Kettwig, Katharina Ternka, Alia Alia, Stefan Nessler, Jutta Gärtner · FENS Forum 2024
We have recently established Rnaset2-/- mice as a model system to improve the pathophysiological understanding of infantile-onset RNaseT2-deficient leukoencephalopathies and type I interferonopathies. Rnaset2-/- mice were viable and healthy at birth, but displayed upregulation of type I interferon-stimulated genes in all organs examined. At 20 weeks of age, RNaseT2-deficient animals developed IFNAR1-dependent neuroinflammation, characterized primarily by the presence of CD8 T cells and inflammatory monocytes. Single nuclei transcriptome analyses revealed homeostatic dysfunction in glial cells
ePoster · Neuroscience