A correlation study between brain lesions and severity of the epileptic syndrome in the pilocarpine model of temporal lobe epilepsy
Elisa Ren, Stefania Bartoletti, Arianna Capodiferro, Beatrice Casadei Garofani, Federica Raimondi, Giuseppina Leo, Giulia Curia · FENS Forum 2024
Temporal lobe epilepsy (TLE) is a focal epilepsy often refractory to anti-epileptic medications. Hippocampal sclerosis and lesions in the temporal cortex are associated to mesial TLE and neocortical TLE, respectively. In both cases, histopathological alterations in other areas have been reported. Here, we investigated the possible correlation between lesioned location and severity of the epileptic syndrome.Status epilepticus (SE) was induced by pilocarpine injection in Sprague-Dawley rats and was terminated 30 minutes later by ketamine/diazepam. Two weeks later, rats were implanted with depth
ePoster · Neuroscience