Differential effects of maternal immune activation on hippocampal DNA methylation and behavior in stress-resilient and stress-susceptible mice
Elad Lax, Raphael Avneri, Dilorom Begmatova, Mali Salmon Divon, Albert Pinhasov · FENS Forum 2024
Background: Past studies have revealed the lasting effects of stress susceptibility and maternal immune activation on hippocampal DNA methylation landscape in adult offspring. Yet, alterations of the DNA methylation landscape during early postnatal development and following maternal immune activation remain less studied. Methods: We used two mouse strains characterized by social dominance (Dom) and submissiveness (Sub), exhibiting inherent traits of elevated and diminished stress sensitivity. Additionally, Poly IC was administered to a subgroup of the dams at gestational day 14 to induce mater
ePoster · Neuroscience