Topic: hippocampal-entorhinal synapses

When animals are placed in multi-compartment or complex environments, entorhinal grid cells exhibit fragmentation of their highly regular spatial tuning curves, with a disjoint grid map for each compartment. However, as the animal explores and increases familiarity with the environment’s geometric and topological structure, the grid maps gradually approach a single globally consistent periodic map [1,2]. Here we show that Hippocampal-MESH — a novel neocortical-hippocampal-entorhinal recurrent circuit model that we introduce in parallel submitted abstracts — can, with the addition of slow plast