Effects of long-term low frequency stimulation on seizures, histopathology, and behavior in a mouse model of temporal lobe epilepsy
Piret Kleis, Enya Paschen, Andreas Vlachos, Ute Häussler, Carola Haas · FENS Forum 2024
Mesial temporal lobe epilepsy (MTLE) is a prevalent form of drug-resistant epilepsy characterized by focal seizures originating from the hippocampus and surrounding structures. Neurostimulation provides an alternative to surgery-ineligible patients with intractable seizures. Hippocampal low-frequency stimulation (LFS) has shown antiepileptic effects in animal studies and small clinical cohorts, yet its long-term effects and mechanisms remain unclear. This study investigates LFS effects on different types of epileptiform activity, spatial learning and anxiety, and synaptic plasticity.We used th
ePoster · Neuroscience