Topic: hippocampal molecular rhythmicity

Introduction: Epileptogenesis is the molecular and cellular process by which a healthy brain becomes an epileptic one. Some evidence suggests that the disruption of circadian rhythms may be impacting the epilepsy phenotype. However, whether the molecular clock is a key player in epileptogenesis remains to be elucidated. Here, we mapped for the first-time the hippocampal molecular rhythmicity of mice during epileptogenesis. Methods: Male adult C57BL/6 mice (n=5/group/Zeitgeber-Times [ZTs]) underwent intra-amygdala kainic acid-induced (i.a.KA) status epilepticus or control (i.a.PBS). From 24h af