Topic: hippocampal mossy fiber synapse

Synaptic transmission is a complex process, which requires activation of presynaptic Ca2+ channels, Ca2+ influx and binding to release sensors. Synaptotagmin 1 (Syt-1) has been previously identified as the primary Ca2+ sensor for fast synchronous transmitter release, while synaptotagmin 7 (Syt-7) was suggested to mediate slower, asynchronous release. However, recent reports have conflicting conclusions on the mechanisms of vesicle release modes, making our understanding of Ca2+ sensing in transmission unclear. To understand the action of synaptotagmins at a central synapse, we performed subcel