Continuous theta-burst stimulation improves learning/memory deficits and behavioral disturbances in the trimethyltin-induced Alzheimer's-like disease model - relevance for the treatment of neurodegenerative disorders?
Marina Zaric Kontic, Milica Zeljkovic Jovanovic, Andjela Stekic, Jelena Stanojevic, Ivana Stevanovic, Dejan Stevic, Milica Ninkovic, Milorad Dragic · FENS Forum 2024
Trimethyltin (TMT)-induced neurodegeneration leads to molecular and behavioral changes similar to those of Alzheimer's disease (AD). Continuous theta burst stimulation (cTBS) has shown promise in psychiatric and neurological disorders but remains largely unexplored in AD models. For this reason, a well-characterized animal model of TMT-induced hippocampal neurodegeneration was used to investigate, for the first time, the effects of cTBS on learning/memory and behavioral disturbances.Adult male Wistar rats were divided into four experimental groups: intact control, TMT (8mg/kg, ip) and TMT trea
ePoster · Neuroscience