Loss of Arc/Arg3.1 during early postnatal development persistently changes hippocampal synaptic transmission in adult mice
Daniela Carolina Ballesteros Cadena, Alexa-Nicole Sliby, Ute Süsens, Dietmar Kuhl, Ora Ohana · FENS Forum 2024
The activity-regulated gene Arc/Arg3.1 is known for its vital role in memory consolidation and synaptic plasticity [1]. Our recent research revealed a novel role for Arc/Arg3.1 in developing brain circuits. In the hippocampus, a spontaneous wave of Arc/Arg3.1 upregulation is observed during the first postnatal month, crucial for establishing proper spatial learning and intact hippocampal oscillations in adult mice [2]. Since the emergence of hippocampal oscillatory rhythms relies on an intricate interplay between excitatory and inhibitory synaptic connections, we hypothesized that early postna
ePoster · Neuroscience