Topic: hippocampal principal cells

The collective spiking activity of hippocampal principal cells supports information processing and integration for memory-guided behaviour. This population spiking is temporally structured and reflect behavioural states. That is, hippocampal principal cell spiking is sparsely paced by theta oscillations during active exploration but tightly synchronised by sharp-wave/ripples (SWRs) during sleep/rest. Notably, previous studies have related SWRs to a current sink in the stratum radiatum, reporting CA3 inputs that serve memory consolidation. Here, we explore whether individual SWRs deviate from t