Topic: hippocampal pyramidal neuron

Neurons are sophisticated input-output devices: their response is driven by the complex interplay between the currents directly evoked by the synaptic stimulus and intrinsic currents controlled by the internal state (e.g. voltage or Ca2+) of the cell. Moreover, the spatially extended dendritic tree of the neurons makes the state variables local. Recruiting local intrinsic currents can fundamentally change the form of input-integration. However, network models ignore the state dependence of neuronal input integration partly because of the lack of information on how intrinsic currents contribute