Topic: Hippocampal sharp wave ripples

The hippocampus plays an important role in memory formation. Hippocampal sharp wave ripples (SWRs) are critical for memory consolidation, during which a large number of hippocampal pyramidal neurons fire synchronously. Recent studies indicate that the participation of hippocampal pyramidal neurons in SWRs is variable. The variability may be explained by gene expression pattterns. However, there are no adequate methods to comprehensively analyze these molecular properties of a single neuron in the context of its electrophysiological spike patterns. Here, we developed an experimental technique t

The dorsal midline thalamus (dMT) is a group of non-sensory thalamic nuclei that has been implicated in arousal and in the homeostatic maintenance of sleep choreography. Neocortical slow oscillations and hippocampal sharp wave ripples (SPW-R) are the hallmarks of non-rapid eye-movement (NREM) sleep and reflect synchronous activation of neocortical and hippocampal neuronal ensembles, respectively. The dMT is reciprocally connected both with the neocortex and with the hippocampal system, however, little is known about their interaction during sleep. We performed large-scale unit recordings from