Topic: hippocampal theta oscillations

Sleep is an essential process observed throughout the animal kingdom, and it is important for memory consolidation. Coordinated neuronal activity occurs during sleep, characterized by distinct events across different sleep states. Non-rapid eye movement (NREM) sleep features slow oscillations, delta waves, thalamocortical spindles and hippocampal sharp waves-ripples, while REM sleep is dominated by hippocampal theta oscillations and ponto-geniculo-occipital (PGO) waves, or pontine waves (“P-waves”) in rodents. Even though their origin from mesopontine cholinergic and glutamatergic nuclei is kn

High frequency deep brain stimulation of the fornix is currently being trialled as a treatment for the memory impairments associated with Alzheimer’s disease (AD), with mixed results. The fornix is a complex white matter bundle linking the hippocampal formation, basal forebrain and diencephalon. Clinicians have suggested that rather than delivering high frequency non-specific stimulation, broader efficacy might be achieved by selectively targeting the distinct neural activities present in the hippocampus, such as theta oscillations. Hippocampal theta oscillations have been strongly implicated