Topic: hippocampal trisynaptic loop

Research into the hippocampus has long emphasized its plasticity (McClelland et al., 1995), though recent reports have highlighted its remarkably stable firing patterns (Mizuseki et al., 2013). How plasticity updates networks maintaining their dynamics remains an open question, largely due to a lack of experimental access points into network stability. Development may provide one such access point. We previously showed that CA1 pyramidal neurons of the same embryonic birthdate exhibit prominent cofiring across different brain states and overlapping place tuning during behavior (Author et al.,