Topic: Hippocampus CA3

Brain machine interfaces (BMIs) are an important technology for restoring mobility in patients with paralysis and a promising tool for understanding the neural correlates of learning. BMIs have been implemented in mice to study decoding and adaptation during volitional activation of single neurons - yet little is known about how learning restructures the broad networks involved. Here we used 2-photon (2P) imaging over eight days as mice learned to volitionally activate pairs of neurons in the motor cortex (MC) or hippocampus CA3 to receive water rewards. We developed an open source pipeline th