Topic: hippocampus neurogenic niche

Ageing is the greatest risk factor for cognitive decline and neurodegeneration. A characteristic of ageing is the loss of proteostasis. Neddylation maintains proteome homeostasis, it is involved in neuronal differentiation and its deregulation is linked to neurodegenerative diseases. The role and mechanisms of Neddylation with physiological ageing remain still unclear.We studied the expression and impact of neddylation on ageing and cognitive decline. We found that neddylation increases with age in the hippocampus neurogenic niche both in human and mouse samples. Aged, but not young, Nae1+/- h