Topic: histone H3 phosphorylation

Epigenetic mechanisms, particularly histone post-translational modifications (PTMs), are pivotal in regulating diverse biological processes, including inflammation and pain. Histone H3 is a crucial protein that significantly regulates gene expression following tissue injury-associated pain. Previously, we found that spinal Pdyn neurons contribute to burn injury-induced heat hyperalgesia via histone H3 phosphorylation-dependent signaling. We suspect that burn injury affects additional histone post-translational modifications beyond histone H3 phosphorylation at serine 10.In our study, we aimed