Seminar · Epigenetics
At the nexus of genes, aging and environment: Understanding transcriptomic and epigenomic regulation in Parkinson's disease
Julia Schulze-Hentrich · Institute of Medical Genetics and Applied Genomics, University of Tübingen
Wed, Jul 20, 2022 · 17:00 UTC
Parkinson’s Disease (PD), the most common neurodegenerative movement disorder, is based on a complex interplay between genetic predispositions, aging processes, and environmental influences. In order to better understand the gene-environment axis in PD, we pursue a multi-omics approach to comprehensively interrogate genome-wide changes in histone modifications, DNA methylation, and hydroxymethylation, accompanied by transcriptomic profiling in cell and animal models of PD as well as large patient cohorts. Furthermore, we assess the plasticity of epigenomic modifications under influence of envi