ePoster · Cognition
You don’t always forget: Mechanisms underlying working memory lapses.
Tiffany Oña Jodar,Genis Prat-Ortega,Eva Carrillo,Chengyu Li,Josep Dalmau,Albert Compte,Jaime de la Rocha · COSYNE 2022
Sat, Mar 19, 2022
Working memory (WM) is central for cognition and is impaired in many brain disorders including those hypothetically mediated by NMDA receptor (NMDAR) hypofunction. Evidence suggests that network attractor states underlie WM maintenance and that failures are mostly caused by fluctuation-driven transitions, but direct evidence for this is still lacking. To investigate what makes WM fail we used a simple two-alternative delayed response task in which mice listen to a lateralized auditory stimulus and, after a variable delay (duration D=0-10 s), they have to lick the associated lateral port. Mice