Glutamatergic neurons in the subthalamic nucleus regulate arousal and REM sleep
Sara Wong, Raquel Yustos, Derk-Jan Dijk, Nicholas P. Franks, William Wisden · FENS Forum 2024
Non-motor symptoms, such as sleep problems, often precede motor symptoms in patients with Parkinson’s Disease (PD). Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used to control motor fluctuations of PD and there is increasing evidence that STN-DBS improves patients’ subjective sleep quality. However, how and if the STN regulates the sleep-wake cycle is unknown. We recorded activity of Vglut2-neurons in the STN during mice’s inactive period (lights on) and found peak calcium signals increased when mice transitioned from NREM to wake (p<0.05) and from NREM to REM (p<0.0
ePoster · Neuroscience