Bidirectional control of BLA-DMS and PFC-DMS projections on innate avoidance behaviour in mice
Luca Fralleoni, Alessia Frenza, Caterina Virginia Addario Chieco, Francesco Gregorio, Arianna Rinaldi · FENS Forum 2024
Avoidance behaviour, aimed at escaping dangerous stimuli and threatening situations, can become maladaptive when individuals avoid relatively safe situations, a hallmark of anxiety disorders. Innate avoidance, a natural aversion to ethologically relevant stimuli, involves a neural circuit in which the basolateral amygdala (BLA) and prefrontal cortex (PFC) play a central role. We have observed that both the PFC and the BLA send converging unidirectional excitatory inputs to the dorsomedial striatum (DMS), which thus may be ideally positioned to regulate the output of this circuit. Indeed, the D
ePoster · Neuroscience