Effects of chemogenetic inhibition of mesopontine cholinergic neurons on REM sleep and PGO waves in mice
Erin Moran, Symeon Gerasimou, Shuzo Sakata · FENS Forum 2024
Sleep is present throughout the animal kingdom, but its function remains to be fully determined. Rapid eye movement sleep (REM) is characterised by muscle atonia, heightened theta oscillations, and the occurrence of ponto-geniculo-occipital (PGO) waves or P-waves. The pedunculopontine and laterodorsal tegmental nuclei (PPT/LDT) have been implicated in REM sleep generation, and their cholinergic neuronal activity was specifically associated with P-waves. However, the precise role of pontine cholinergic neurons in REM sleep remains elusive, particularly their impact on sleep architecture and P-w
ePoster · Neuroscience