Exploring the potential of induced neural stem cells (iNSCs) as therapy for spinal cord injury in a rat model
Ibrahim Khan, Lara Bieler, Katharina Günther, Dominika Jakubec-Haščák, Felix Hübl, Jaqueline Illek, Marta Suarez-Cubero, Frank Edenhofer, Sebastien Couillard-Despres · FENS Forum 2024
Spinal cord injury (SCI) is a severe condition associated with high morbidity and mortality rates. As of now, no effective therapies are available. However, induced neural stem cells (iNSCs) offer a promising therapeutic approach by enabling autologous transplantation.In the subchronic phase 30 days post-SCI, we conducted the transplantation of fGFP-labelled human iNSCs (or vehicle) into female Fischer-344 rats with moderate to severe spinal cord injuries at the T8 level. One day prior to cell transplantation, immunosuppressive treatment was started and maintained to prevent graft rejection th
ePoster · Neuroscience