Quantitative analysis of neural activity in the ventral nucleus of the medullary reticular nucleus in mice developing spasticity after stroke using activity-dependent manganese contrast-enhanced MRI
Sachiko Hotta(Lee), Shogo Isumi, Hirohito Kan, Makoto Osanai · FENS Forum 2024
Spasticity, characterized by increased spinal stretch reflexes, appears after a certain period following stroke and it is impaired sever skilled movement by spasticity. The mechanism in the cerebral neuronal circuitry is still largely unknown. This present study focused changing of neuronal activity on the ventral medullary reticular nucleus (MdV), which has been recognized as the region associated with skilled movement. Quantitative activation-induced manganese-enhanced MRI is noninvasive measurement of the history of neuronal activity. Manganese ions (Mn2+) enter and accumulate in active neu
ePoster · Neuroscience