Topic: homeostatic gain modulation

Diversity exists all throughout biology where it plays an important role in maintaining robustness and stability [1]. The same is true of the brain [2], as has become increasingly apparent in recent years with the accumulation of datasets of unparalleled resolution [3,4]. These datasets show heterogeneity in the brain to be widespread, spanning cells, circuits and system dynamics, marking it as an unavoidable component of neuronal composition. Recent experiments found that decline in biophysical heterogeneity amongst neurons may accompany pathological states such as epilepsy [5]. While heterog