Methyldonor supplementation protects against early-life stress induced emotional dysregulation via modulation of hypothalamic DNA methylation
Natalia Schilder, Kitty Reemst, Veronica Begni, Moshe Szyf, David Cheishvili, Marco Riva, Aniko Korosi · FENS Forum 2024
Exposure to early life stress (ELS) leads to an increased risk for psychopathology and emotional dysregulation. Knowledge on underlying mechanisms and interventions are lacking. We previously found that early methyldonor supplementation protects against ELS-induced cognitive deficits, mediated partly by HPA-axis modulation. Methyldonors are essential micronutrients and key for methyl group generation for methylation of DNA and histones. Our study aimed to understand how ELS and early micronutrient intervention affect (i) HPA-axis responsivity and anxiety/depressive-like behavior, and (ii) hypo
ePoster · Neuroscience