Human pluripotent stem cell-derived ectomesenchymal cells promote neurogenesis and neurite outgrowth in rats with hypoxic-ischemic brain injury through the ERK/CREB signaling pathway
Jiawei Huang, Qingwen Deng, Xiaohua Jiang · FENS Forum 2024
Our previous study found that ectomesenchymal stem cells derived from human pluripotent stem cells (hPSC-EMSCs) exhibited higher neuroprotective potential than hUC-MSCs, as evidenced by a more significant reduction in lesion size and apoptosis in rat brains after hypoxia-ischemia (HI). Moreover, in vitro studies demonstrated that hPSC-EMSC-derived conditioned medium (CM) had neuroprotective and neurorestorative effects through the promotion of anti-apoptosis, neurite growth and neurogenesis. In this study, we discovered that hPSC-EMSCs and hUC-MSCs expressed differential secreted factors by ut
ePoster · Neuroscience