IL-4-induced microglia-derived small extracellular vesicles exhibit cytoprotective effects against LPS-induced microglial damage through miR-191-5p
Aysen Cotuk, Burak I. Arioz, Cagla Kiser, Tutku Yaras, Alper Bagriyanik, Gökhan Karakülah, Pembe Keskinoglu, Sermin Genc, Kemal Ugur Tufekci · FENS Forum 2024
Microglia are the resident immune cells of the central nervous system and play a vital role in cytoprotection by maintaining brain homeostasis via direct interaction and/or secretion of molecules and vesicles with neurons, other brain cells, and even themselves. Extracellular vesicles are involved in cell-to-cell communication by transporting bioactive molecules, such as miRNAs, to recipient cells. microRNAs (miRNAs) are small noncoding RNAs that contribute to gene expression by silencing mRNAs, and it has been demonstrated that the content of the small extracellular vesicles includes miRNAs.
ePoster · Neuroscience