The mechanism underlying acupuncture inhibition of addiction behaviors through activation of mesolimbic GABA neurons
Han Byeol Jang, Hyung Kyu Kim, DanBi Ahn, Bae Hwan Lee, Bong Hyo Lee, Hee Young Kim · FENS Forum 2024
Our previous studies have suggested that acupuncture modulates the mesolimbic dopamine(DA) system, a region implicated in drug abuse. Therefore, in this study, we hypothesized that the stimulation of acupuncture activates mesolimbic GABA neurons in the ventral tegmental area(VTA), thereby affecting the inhibition of addictive behavior. Cocaine injections and LI5 acupuncture stimulation significantly increased locomotor activity, but HT7 acupuncture inhibited cocaine-induced locomotion. In vivo fiber photometry showed that HT7 stimulation significantly activated VTA GABA neurons compared to con
ePoster · Neuroscience