Topic: hTrkB-Y433F mutant mice

Environmental enrichment can be defined as external stimulation by the physical or social surroundings. Classical and rapid-acting antidepressants have been shown to bind directly to BDNF receptor TrkB to promote neuronal plasticity. Like antidepressants, environmental enrichment has been shown to promote neuronal plasticity in the brain, although the exact mechanisms of action are unknown. Environmental enrichment could thus potentially act as a complementary or alternative non-pharmacological treatment for neuropsychogical disorders. This study investigated the effect of 10 weeks of environm