Retinal dysfunction in Huntington’s disease mouse models is characterized by an early photoreceptor degeneration and a late neuroinflammation
Jorge Navarro Calvo, Paula Martín-Climent, Fátima Cano-Cano, Francisco Martín-Loro, Samanta Ortuño-Miquel, Gema Esquiva, Violeta Gómez-Vicente, Ana I. Arroba, Luis M. Valor · FENS Forum 2024
Huntington’s disease (HD) is a fatal neurodegenerative disorder known for thirty years to be caused by an aberrant expansion of CAG repeats in the HTT gene. Still, no specific biomarkers are routinely applied in the clinical management of patients. The retina is the most accessible area of the CNS system that enables noninvasive monitoring of HD mutation carriers, but we need first to determine how retinal alterations correlate with those of inner brain areas. To this aim, we analyzed the transgenic R6/1 and the knockin zQ175 mouse strains using optical coherence tomography (OCT), gene express
ePoster · Neuroscience