Topic: human airway epithelial cells

Recently found association linking viral infections to neurodegenerative diseases has raised concerns about unknown mechanisms in the communication between the respiratory and central nervous systems . We hypothesized that extracellular vesicles (EVs) can transfer viral signals to microglia, triggering the upregulation of pro-inflammatory cytokines by activating inflammasome-related pathways. In this study, we investigate the role of EVs released from virus mimetic poly I:C-infected human airway epithelial cells in modulating microglial immune responses. EVs were isolated from poly I:C-primed