Homeostatic plasticity of human layer 2/3 cortical pyramidal neurons
Verjinia Metodieva, Ran Xu, Julia Onken, Ulrich-Wilhelm Thomale, Thomas Sauvigny, Thilo Kalbhenn, Matthias Simon, Henrik Alle, Martin Holtkamp, Pawel Fidzinski, Jörg Geiger, Dietmar Schmitz, Rosanna Sammons · FENS Forum 2024
The brain undergoes constant activity fluctuations related to processes like learning, development, and sleep. Neuronal plasticity enables information storage relevant to those changes but also serves to regulate stable neuronal firing. Homeostatic plasticity mechanisms protect neurons from activity extremes that are associated with pathological conditions such as mood disorders, epilepsy, and dementia. Our aim is to assess how targeted human brain neurons and the synaptic connections between them adapt to prolonged elevation of activity. To assess plasticity, we perform whole-cell patch-clamp
ePoster · Neuroscience