Understanding molecular mechanisms in oligodendrocyte development in vitro using human fetal neural stem cells
Sudip Sen, Sagar Tyagi, Vadanya Shrivastava, Devanjan Dey, Sweety Rani, Jai Bhagwan Sharma, Jayanth Kumar Palanichamy, Subrata Sinha, Pankaj Seth · FENS Forum 2024
Oligodendrocyte (OL) development undergoes a maturation arrest when premyelinating OL prevalent in preterm fetuses, are exposed to hypoxic injury. Understanding molecular mechanisms controlling OL development may help develop therapeutic strategies in conditions like cerebral palsy. Human fetal neural stem cells (FNSCs) were differentiated into OL and transcriptional changes were analyzed (RNA sequencing). The JAK-STAT cell signaling pathway was implicated in terminal OL maturation. The MO3.13 cell line resembling premyelinating OL was differentiated into mature OL over 7 days, using phorbol 1
ePoster · Neuroscience