Topic: Human genetic variants

Seminar: 1 seminar

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Neuroendocrinology

SeminarNeuroendocrinology

Some new insights into the central sensing of nutritional state and somatic stress

Stephen O'Rahilly

Wellcome-MRC Institute of Metabolic Science, University of Cambridge

Jun 28, 2021

This talk will focus on two areas. I will firstly discuss some new data, starting with insights from rare human genetic variants, which helps to clarify the role of the central melanocortin system in the acquisition of nutrients and their disposition into growth, the acquisition of lean mass and sexual maturation . I will then discuss some aspects of the emerging biology of GDF15; a sentinel hormone conveying information regarding a range of somatic stresses to the brain.