Topic: human keratinocytes

Solar ultraviolet B (UVB) radiation is known to incite excessive inflammatory reactions that compromise the integrity of the skin's epidermal barrier and may ultimately contribute to the onset of skin carcinoma. Prior investigations have determined that following exposure to UVB, epidermal keratinocytes commence the synthesis of β-endorphin, a peptide derived from proopiomelanocortin, which possesses an analgesic property. Nonetheless, the specific functionality of β-endorphin within the context of skin subjected to UVB exposure remains inadequately elucidated. The current study thus pursued a