Investigating Parkinson's disease using patient-derived iPSCs transplanted in a human-mouse chimera model
Stefano Frausin, Chiara Pavan, Dad Abu-Bonsrah, Serena Viventi, Niamh Moriarty, Louise Cottle, Deniz Kirik, Clare Parish, Lachlan Thompson · FENS Forum 2024
Parkinson’s Disease (PD) is a neurodegenerative disorder characterised by progressive and selective neuronal loss of specific brain regions, including brainstem and cortical regions. Mutations and/or deletions in specific genes result in a high probability of developing PD characterised by distinct presentation. For example, complete loss of parkin function (PRKN KO) causes early onset PD and motor deficits due to the ventral midbrain dopaminergic neurons (VmDA) degeneration. Patients with disease-causing mutations in SCNA and LRRK2 genes show a widespread pathology with high aggregate burden
ePoster · Neuroscience