Topic: human neurogenesis

The transcriptional co-activator Yes-associated protein-1 (YAP) and its paralog WW domain-containing transcription regulator 1 (WWTR1, TAZ) are known to regulate organ size, proliferation, and stem cell signaling in multiple tissue systems. However, their roles in nervous system development and neuronal differentiation have been understudied. Here, we set out to characterize YAP/TAZ expression changes and function in human neurogenesis in a cell lineage-specific and/or developmental stage-specific manner. To this end, YAP and TAZ knockouts were created in human embryonic stem cells using CRISP