Melatonin-preconditioned human olfactory mucosal ectomesenchymal stem cells to treat spinal cord injury in rat
Hatef Ghasemi Hamidabadi, Sohelia Adhami, Martam Nazm Bojnordi, Koroosh Shapasand · FENS Forum 2024
Aim: Spinal cord injury (SCI) triggers inflammatory response by activation and accumulation radical oxygen species (ROS). Cell therapy has no effective long term recovery outcomes due to presence of ROS in lesion site increase the death rate of transplanted cells.One efficient approach to address this issue is adding adjuvants like neurotrophic factors and antioxidants, among them melatonin has been reported to play a key role in neuroprotectection. The melatonergic treatment is remarkably associated with scavenger oxidative stress and cell proliferation. The purpose of this study is the impac