Machine Learning Approaches Reveal Prominent Behavioral Alterations and Cognitive Dysfunction in a Humanized Alzheimer Model
Stephanie Miller, Nick Kaliss, Pranav Nambiar, Jorge Palop, Kevin Luxem, Yuechen Qiu, Catherine Cai, Kevin Shen, Takashi Saito, Takaomi Saido, Alexander Pico, Reuben Thomas, Stefan Remy · COSYNE 2023
Behavioral manifestations define neurological disorders, but our knowledge of disease-induced behavioral alterations is incomplete and largely limited to standard domain-specific behavioral approaches. New humanized App knock-in (KI) models of Alzheimer’s disease (AD) mimic disease mechanisms better than transgenic overexpression, but fail to display consistent behavioral alterations in standard behavioral tests despite severe AD-related neuropathological changes. To address this technological barrier in AD modeling, we used the machine learning platforms DeepLabCut and VAME to test the hypoth
Fri, Mar 10, 2023