Lateral hypothalamic neurotensin-expressing neurons shape the balance between drinking, feeding, and socializing
Chantal Wissing, Anne Petzold, Hanna van den Munkhof, Tatiana Korotkova · FENS Forum 2024
In the lateral hypothalamus (LH), distinct cell populations modulate innate behaviors. We investigated the role of neurotensin-expressing (Nts) neurons in the LH in balancing feeding, drinking, and social behavior across internal states.In vivo calcium imaging in freely behaving mice revealed distinct activity patterns of Nts-LH neurons associated with water and food stimuli. After prolonged food restriction, water responses were strongly enhanced, suggesting that Nts-LH neurons are involved in maintaining water intake during hunger pressure. Activation of Nts-LH neurons counteracted hunger pr
ePoster · Neuroscience