A chemosensory role of cerebrospinal fluid (CSF)-contacting neurons in detecting and responding to pathological changes in cerebrospinal fluid
Feng Quan, Hugo Marnas, Andrew E Prendergast, Ki Jim Kin, Loéva Tocquer, Louis Moizan, Claire Wyart · FENS Forum 2024
A century ago, Kolmer and Agduhr identified ciliated neurons in the spinal cord that contact cerebrospinal fluid (CSF) across vertebrate species. These neurons, called spinal CSF-contacting neurons (CSF-cNs), modulate locomotion and posture by detecting mechanical and chemical cues from the CSF. However, the mechanisms by which CSF-cNs detect and respond to CSF changes are unknown. In this study, we investigate whether CSF-cNs in larval zebrafish can detect and respond to pathological CSF changes induced by a ventricular injection of Streptococcus pneumoniae (S. pneumoniae), the major pathogen
ePoster · Neuroscience