Hyperglycemia affects mitochondrial respiratory chain but not the hydrogen peroxide production in neurons during ischemic stroke
Kseniia Morozova, Daria Kotova, Aleksandra Ivanova, Matvei Pochechuev, Ilya Kelmanson, Yulia Khramova, Alisa Tiaglik, Mark Sudoplatov, Arina Trifonova, Anna Fedotova, Veronika Katrukha, Anastasia Sergeeva, Roman Raevskii, Mariia Pestriakova, Maxim Solotenkov, Evgeny Stepanov, Aleksandra Tsopina, Aleksandr Moshchenko, Milena Shestopalova, Anton Zalygin, Ilya Fedotov, Andrei Fedotov, Vladimir Oleinikov, Vsevolod Belousov, Alexey Semyanov, Nadezda Brazhe, Aleksei Zheltikov, Dmitry Bilan · FENS Forum 2024
Diabetes has a systemic effect on the metabolism and can be linked to higher risks of severe medical conditions, such as ischemic stroke. Hyperglycemia leads to more extensive cerebral damage during stroke and, as a result, to more severe consequences. One of the main damaging factors of the stroke is the reactive oxygen species generation occurring in mitochondrial respiratory chain (electron transport chain, ETC). We used in vivo Raman microspectroscopy with the chronic cranial windows implantation to assess the redox state of mitochondria ETC in neurons of awake mice under normal and hyperg
ePoster · Neuroscience