Deciphering the mechanisms underlying auditory hyperexcitability in a genetic mouse model susceptible to audiogenic seizures
Sabrina Mechaussier, Mathilde Gagliardini, Carolina de Campos Pina, Olivier Postal, Typhaine Dupont, Boris Gourevitch, Nicolas Michalski · FENS Forum 2024
An exquisite characteristic of the auditory system is its ability to sense a large range of sound intensities from whispers to loud alarm sounds, covering 6 orders of magnitude in acoustic pressure. Deficits of sound intensity processing may lead to hearing loss and/or major auditory perception distortions like tinnitus, the perception of phantom sounds, or hyperacusis, a reduced tolerance for moderate sound levels. Audiogenic seizures, reflex seizures induced by loud sounds, are a common feature of many mouse models for central nervous system disorders and may be seen as a model of auditory h
ePoster · Neuroscience