Centrally located transient receptor potential ankyrin 1 ion channel may exert diverse impact on the symptoms of posttraumatic stress disorder in mice
János Konkoly, Viktória Kormos, Balázs Gaszner, Dóra Zelena, Erika Pintér · FENS Forum 2024
Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in the urocortin 1 (UCN1) positive neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) having modulatory impact on stress adaptation. As post-traumatic stress disorder (PTSD) is triggered by disturbed stress adaptation, we hypothesized the regulatory role of EWcp/UCN1/Trpa1 neurons in PTSD.Methods: Male TRPA1 wild-type (WT) and knockout (KO) mice were exposed to two different models of PTSD. In single prolonged stress (SPS) paradigm, time spent immobility was measured during
ePoster · Neuroscience