Topic: hyperphosphorylated Tau protein

Alzheimer's Disease (AD) are characterized with the accumulation of hyperphosphorylated tau protein and Aβ and neuroinflammation. Disrupted myelin has been observed in the brains of AD patients before the onset of symptoms. However, it remains unknown the function of myelin-forming cells in AD pathogenesis. Oligodendrocyte precursor cells (OPCs) are the source cells of myelin-forming cells in the central nervous system (CNS). In this study, we observe an abnormally enhanced microglial phagocytosis upon in activation of autophagy in OPCs. AD transgenic mice harboring defective autophagy exhibit