Effects of partial lesions of hypocretin neurons in the lateral hypothalamus on sleep in rats
Mariia Lebedeva, David Levčík, Jan Kudláček, Kristýna Malenínská, Iveta Vojtěchová, Helena Buchtová, Hana Brožka, Dominika Radostová, Erika Petránová, Přemysl Jiruška, Aleš Stuchlík, Jan Svoboda, Eduard Kelemen, Štěpán Kubík · FENS Forum 2024
Hypocretin(orexin)-producing neurons in the lateral hypothalamic area are important for sleep regulation and their damage manifests clinically as narcolepsy in humans. In animal experiments, extensive lesions of these neurons confirmed and clarified their physiological importance. Smaller, partial lesions of hypocretinergic neurons may uncover more subtle mechanisms of function of hypocretin system and may help understand more delicate processes in early stages of pathogenesis of narcolepsy. In a lesioned group of rats (N=9) bilateral injections of hypocretin-2-saporin (Hcrt2-SAP) conjugate in
ePoster · Neuroscience