Topic: hypoxic-ischemic brain injury

Neonatal ischemic stroke is a significant cause of mortality, severe developmental delays, and spastic cerebral palsy. In most cases, ischemic stroke occurs in the basin of the middle cerebral artery. Middle cerebral artery occlusion is the well-established model for stroke in adults. However, this method is mostly described in rat pups and is not well-established in neonatal mice.In this study, we compared a model of neonatal stroke (tfMCAO, transient filament middle cerebral artery occlusion) with neonatal hypoxic-ischemic brain injury (RVM, Rice-Vannucci model of unilateral carotid ligation