Neuroprotective effects of cannabidiol: Shifting microglia phenotype and preventing neuronal death in a neonatal hypoxia-ischemia model
Jaume Lillo Jové, Iu Raïch, Laura Silva, Alejandro Lillo, Carlos Ferreiro-Vera, Verónica Sánchez de Medina, José Martínez-Orgado, Gemma Navarro, Rafael Franco · FENS Forum 2024
Neonatal hypoxia-ischemia is a severe condition that can result in death and/or lifelong central nervous system sequelae. Benefits of cannabidiol (CBD) result from neuroprotection asssumed to be mainly due to targeting a variety of neuronal receptors. The results of this article first show that CBD protects both primary neurons and primary glia against death induced by glucose and oxygen deprivation. Second, the expression of glial markers in an animal model of neonatal hypoxia-ischemia treated with vehicle or CBD shows that the cannabinoid was able to skew microglia towards a neuroprotective
ePoster · Neuroscience